Endothelial Response to Pathophysiological Stress

Heterogeneous response of microvascular endothelial cells to shear stress.

We investigated changes in calcium concentration in cultured bovine aortic endothelial cells (BAECs) and rat adrenomedulary endothelial cells (RAMECs, microvascular) in response to different levels of shear stress. In BAECs, the onset of shear stress elicited a transient increase in intracellular calcium concentration that was spatially uniform, synchronous, and dose dependent. In contrast, the...

Endothelial dysfunction in response to psychosocial stress in monkeys.

The current study was designed to evaluate the effects of a disrupted social environment on the endothelial integrity of various vascular segments in male cynomolgus monkeys (Macaca fascicularis). Each of 20 single-caged adult monkeys was fed a diet comparable to a person's ingestion of 240 mg cholesterol/day for a 10-week baseline period and then was introduced as a stranger into a four-member...

Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress.

Atherosclerotic plaques can lead to partial vascular occlusions that produce abnormally high levels of arterial wall shear stress. Such pathophysiological shear stress can promote shear-induced platelet aggregation (SIPA), which has been linked to acute myocardial infarction, unstable angina, and stroke. This study investigated the role of the tyrosine kinase Syk in shear-induced human platelet...

Stress echocardiography. From pathophysiological toy to diagnostic tool.

Stress echocardiography today enters the clinical arena as a safe and efficient option for diagnostic imaging of myocardial ischemia in the nineties. It is no longer considered an esoteric research tool in the hands of few high-tech laboratories but rather an extension of daily echocardiographic diagnosis.12 This article will briefly review the basic features of this new method: the pathophysio...

Response of two soybean cultivars to moisture stress